Restrictive cardiomyopathy, also known as fibroplastic parietal endocarditis with blood eosinophilia, is associated with impaired relaxation and diastolic filling of the heart.
- Eosinophils infiltrate the endomyocardium in an abnormal infiltration, causing tissue damage from degranulation that ultimately results in fibrosis.
- In other words, since the severity of initial eosinophilia directly correlates with the severity of acute myocarditis, patients with low to moderate levels of eosinophilia may only experience low-grade endomyocarditis that is not always clinically evident. However, this inflammation eventually still results in progressive fibrosis.
- The patient is only diagnosed with fibrosis after developing symptoms. At this point, there are few options for management, and typically only two options left: Heart failure medications and Surgical intervention.
- Due to mitral regurgitation, Loeffler endocarditis patients typically require mitral valve replacement.
- A biological valve is preferred over a mechanical valve due to the high incidence of mechanical valve thrombosis. The mitral valve may be switched with a mechanical or biological prosthetic valve.
- Since Loeffler endocarditis can be fatal, it must be diagnosed and treated immediately.
- Individuals with a history of hypereosinophilia should be closely watched for the onset of thrombosis and fibrotic, restrictive cardiomyopathy.
- Surgical intervention may be necessary to stop morbidity and mortality if the disease is discovered later in the disease process and fibrotic disease has already begun to develop.
- Treatment with steroids and cytotoxic drugs can be helpful if the disease is discovered early.
Common cold,Asthma,Rhinitis,Urticarial, or other allergic disorder, Chest palpitations,Dizziness,Light headedness,Fainting
Poor heart contractility,Irregular pulse and heart rate,Asthma,Rhinitis,Urticarial
Diuretics,Digoxin,Angiotensin-converting enzyme (ACE) inhibitor angiotensin II receptor blockers,Beta-adrenergic blockers,Aldosterone antagonists