Hypertrophic cardiomyopathy is a genetic disorder that affects the heart muscle. It can be caused by a mutation in one or more of several genes, including MYBPC3, TNNT2, and TNNI3. The mutation can cause the heart to grow abnormally large and make it harder for it to pump blood throughout your body.
This condition is often referred to as HCM, but it's important to understand that there are different types of hypertrophic cardiomyopathy. Nonobstructive hypertrophic cardiomyopathy (HCM) is a type of HCM in which there is no obstruction of blood flow through either one of the heart's main arteries (the left main coronary artery). In obstructive HCM, there is an obstruction in one of these arteries that must be surgically treated before symptoms develop.
There are a number of causes for nonobstructive hypertrophic cardiomyopathy. The most common cause is idiopathic, meaning that the cause is unknown. Other possible causes include:
* Anabolic steroid use
* Alcohol abuse
* Cocaine abuse
* Coronary artery disease (CAD)
* Large left atrium (LA) or ventricle (LV) with normal coronary arteries and no valvular abnormalities
There are several possible causes for nonobstructive hypertrophic cardiomyopathy, including genetics and environmental factors.
Genetics: The cause of HCM is not known, but researchers have found that it tends to run in families. Most people who have this condition inherited it from their parents, who may have passed along a genetic mutation causing the disease. These mutations can be passed from parent to child through generations.
Environmental factors: Nonobstructive HCM can also be triggered by environmental factors such as smoking and high blood pressure. In some cases, it's known that these environmental factors caused the disease in an individual, but researchers don't know how often this happens or what exactly causes it.